A few people have said what I'd say so far, like Mbam, I agree. Not to discourage a repower, but to consider how realistic it'll be and what your expectations are.
Not having done what you're considering, but something much milder, personally I wouldn't even consider trying to turn a high profile pocket cruiser into a go fast. Bigger motor to reduce the "sluggish" underpowered feel sure, but you'll find you'll get to a point, and it'll come quick, when the math no longer works and you're trying to push a tank through a wall with a tricycle.

(I made that up)
So, my story, I have a 240 Searay Sundeck. Advertised 4900# dry, 65 gallons fuel, 20 gallons water and all the normal gear plas what we bring (like the 200# ice chest

) so we're pushing close to 6000# on the water. Original motor was a 7.4 MPI. They have plenty of torque for boats in the size range, made a good single power for smaller < 27'-28' cruisers but no top end to speak of which is perfect. Compared to the same boat with a 350 mag, it was much more responsive, quicker to plane and a little more top end simply because it can turn a larger 26p prop (2.0 gear) and it wasn't working as hard.
Fast forward to today. It's got a mild 540, mild in that it makes peak HP at 5300 (per PS dyno). I went to a cupped 30p BIII prop and now, I have about the best balance of performance that I can expect. At this point I'm against the hull, it just isn't made to run high speeds so mid 60's is it. In my case it's a very solid boat so at 65 MPH it's very stable, even in a little bit of rough water but with the huge wetted surface and the hull design itself, it's the 48000# gorilla I'm pushing at that point. And it's a deep v, 21* deadrise sport boat hull.
The BIII is still going strong at about 150 hours with the new power, but I'm easy on it. The best part is the enjoyment I get from the nice putt-putt cruise at 35-40 MPH. > 50-55 MPH is when it starts to have to work a little but when the same boat is working hard at 35-40, I'm waving as I go by at 50+. I spend most of the time between 2600 and 3200 RPM.
That said, I probably would not do it again simply because, it's over-kill for a boat like this and isn't necessary for 95% of our boating. I'd have a hard time giving up the torque of a BB, I admit, but this much isn't needed. I also have to admit, I enjoy having the power every now and then. It's a definite sleeper.
How often will you be running 65-80 MPH "if" you're able to get the power you're planning with a drive that will handle it?
How bad will the torque/list be?
How stable is that much boat with that deep hull, trimmed out and up on plane even if you can get a flat attitude?
How much torque/stress will the hull take before you start seeing problems/failures?
I think I'd save the $30k-40k you'll spend in the motor and drive (if not more) and repower with a 496 take-out and start planning a go fast, or start looking for a sport cruise designed for your boating style. Just my honest opinion.
Mine could easily make a lot more power but the goal was displacement to keep a pleasure boat a pleasure boat plus some.
I think what I did was crazy; I can't even imagine what you're considering.
