I've talked to lot of people that have made the trip up the Calloosahatchee to the locks and the say it's worth taking. In fact I want to make the trip all the way across the lake from Ft Pierce to Ft Meyers.
I've read a lot of articles and they give great info about trip. Call Southern Boating in Ft Lauderdale and see if they can send you articel from archives. Also might want to get some navigation software called First Mate from www.thecapn.com and take the trip for practice on your computer. It will show a lot of the detail you need to knoe before you take the trip.