For a concealed carry weapon I would go with the .40 cal Glock. The only safety to deal with is on the trigger which is automatically disengaged when pulling the trigger (and if you are taught correctly you should not have a finger on the trigger until ready to shoot). The .40 is a great "people stopping" round. I would stay away from the 9mm and .380 as Troutly stated, they are not as effective in stopping power. I also have a "mini glock" .40 which is very small and easy to carry but still fires a good effective round.