The hardest thing on the engines is RPM, not boost. So if you want to keep your engine close to stock hours, then you'll need bigger props if your going to constantly be running top speed. For most, they just occassionaly take it up and this has very little change on the life of the motor.
Trans and drive has proven to handle the power.
You do not need to pull the motors all the time, even in stock form, the first thing to go is going to be the valve train, followed by head gaskets, so you should rebuild these around 300-400 hours no matter what.