Disappearing Islands is good on weekends, it is directly inside Ponce Inlet (inlet separates Daytona from New Smyrna. Back side is navigatible and ideal to stay away from boat wakes.
Boat ramps at Port Orange or Halifax Harbour in Daytona. Halifax has fuel, 5-6 ramps, fresh water for flushing and even an onsite West Marine store. Both ramps are on the ICW. Nice day trip is to take ICW north to St Augustine, very few no wake zones (one long one right in Daytona, like 1 mile+). You can make St Augustine in an hour or so.
Channel markers don't lie, I have bumped ground in a 15 Whaler 10 feet outside a channel. Water is dark, not great visibility. ICW is wide open, be on the look out for manatees and dolphins, they are everywhere.