Perdido to Destin is a BIG area. If you choose the western end (Perdido) you might try Nolan's in Gulf Shores. There's also a rooftop restaurant/bar at MM4 Gulf Shores. It was formerly called The View but has changed its name and I can't recall the new one. You can't miss it. It's on the 9th floor of a racquet club...the only tall building there. Be there at sunset if possible.
If you go to P-cola you can't beat Jackson's downtown or Chan's in Pen Beach. BoyOn A Dolphin is fine Greek food. Also on the west end the best seafood and social action will be found at Live Bait. McGuires in P-cola is always hopping.
It's hard not to have a good time in this area. Enjoy.