Those 425hp engines you have are going to want to BREATH and installing those CMI's should wake those things up and increase your RPM's by roughly 300-500rpm---but that is just a guess on my part.----But it should be interesting because if you are now only running the stock Merc cast iron exhaust system it is pretty restrictive and very crude! And the more horsepower you have the more restrictive it can be on an engine. I'm not sure how much weight you'll save with the CMI's, but they are going to dress up your engines much nicer and be more eye appealing when you lift the hatches for your friends to see---plus they are going to have a MUCH better sound and rumble to them.
If you are going with a Holley carb a 800cfm would be okay, but a 750cfm is all you need on a 454 and will give very crisp throttle response and that's what you want in a marine engine.
Keep us posted as to what the out come is with the performance of your boat with these mods you are doing. My guess is that it will be a real eye opener once you bolt on those CMI exhausts!---- Have fun!