Anyone know of a safe place with ramp to leave truck and trailer while overnighting in the area. Also looking for advise where to anchor out and a bath house.

Salty Sams Marina has a ramp and lots of cameras. There is a mooring field near their marina as well

I see you have a 25'. I'm a 30 and loved this place. Bad lil ramp and shallow creek in and out BUT very cool lil neighborhood bar and 15$ a night dockage. I had no problems watching tides. 20 min run out to Estero Bay and the owner lives there to watch your rig. I sleep at the docks 2-3 nights. No ahower but bathroom.
http://thecreekshack.com/

Is it a fresh water creek?

Your best bet would to use Punta Rassa boat ramp at the foot of the Sanible Bridge. Nice ramp, good parking and right at the mouth of the gulf.

what about showers? I see outdoor showers at Lovers Key, and boat ramps. Punta Rassa looks like a great location, but no showers.

lovers key great ramp and location