2000 - 382 with a kenwood factory stereo set up, I was running on Sat and when I arrived at my destination I went to turn on the stereo and only have sound in the front (cabin) speakers, totaly lost the sound in the cockpit speakers.

I did check the stereo setting for balance to rear & front that is not the issue. I am hoping some of you stereo experts can guide me in what to check or look for. I am thinking it has to be either a main wire from the stereo/amp that came off or can it be one of the amps that can go bad, there are two in the cabin below the sink.

Check for power at the amp on both the red and blue remote wires. They both have to have power when the head unit is on.

Might have blown a fuse in an amp. Without knowing exactly what you have for amps and how they are wired, it will be tough to troubleshoot.