Plus Man

I spent many hours tunning in my 454 mag with a procharger. I have upgraded my fuel system with all areomotive parts. my question is I have tunned it using a rising rate fuel pressure regulator . Should I be tunning it with the fuel pressure set at max fuel pressure at wide open and not use the rising rate regulator to increase fuel pressure at boost . I have the ability to tune the fuel map as I have a mefi burn program.