I have ran them this way in the past with no problems. However I now plumb the intercooler off of an extra bung on the sea strainer. This is actually the bung I use to use a high pressure relief. I am running a cat with a very shallow pickup, one sea strainer per motor, one pickup per motor, 1300hp quad rotor motors, and I have had no water pressure or temp problems. This also helps to reduce drag on the bottem of the boat. I like the looks of the pickup in the pics, but I don't like haveing all those hole in the bottom to disrupt the water flow.

Yes the holes could have been counter sunk better.

42MTI, are you running a line from the main strainer directly to the intercooler and the other bung on the strainer goes to the engine seawater pump? In other words the intercooler and engine operate off the same strainer?

Exactly

42MTI, have you ever noticed flow from the intercooler at speed? The reason I ask is that I put a pressure guage on one of my existing strainers. I am running a two stage KE sea water pump. At idle I pull about -10# at the cooler which makes sense as the pump is pulling water into the boat thru the transom pickup or any other opening including a cooler if you have one. It could also pull air thru the intercooler thru the dumps from the cooler. At around 50+ mph in my boat at least, the pressure in my strainer approaches 0 which means that the transom pickup is generating it's own pressure and begining to overcome the negative pressure created by the sea water pump. If you have a one way valve on the feed to the intercooler then you are fine. Just a thought.

For information

I have pick ups for my motors so I use the pick up from my drives to feed my chillers.

I would not put chillers on pumps running from the motor, on idle it will re-liquify your mixtures and give you headaches idling.

Just my humble opinion.