After wiping a lobe off of my camshaft I realized that a lot of material went through the motor is it good practice to block off the oil filter bypass or will I be asking for problems

It is a gen 4 454 with a hv oil pump

Yes - good idea to block it off - I used a frost plug.

i agree,block it off,most hp adapters dont have a bypass to block.

Don't forget to change the oil cooler also. I have seen metal everywhere. In the piston skirts, lifters, coolers, oil cooler hoses, valve guides, fuel pumps (MarkIV).

Sorry to hear about your problem, most of us have been there one time or another.

unfortinatly,flat tappit cam cores are being imported from china,and are junk,i highly recommend going with a hyd roller if it is in the budget.im rebuilding a merc 370 hp rebuild for someone now and im worried about the new flat tappet cam,even with proper break in they still go flat.if you do use a flat tappet cam,make sure you use a good break in oil and add zddp to it.

My roller cam will be here tomorrow the old cam was a crane flat tappet and I used Brad Penn and Lucas zinc additive and it still wiped the lobe off in 20 min I am done with flat tappets.

I thought the cooler was after the filter if this is the case what is the possibility of debris getting in their?

Not all are plumbed like that you might want to double check. You should probably discard the oil cooler though.
At minimum put the filter after the cooler if it is not.

mike,,i have had great luck with crower cam saver lifters,crower grinds a flat spot on the lower half of the lifter,when it spins it dumps oil on the camshaft..