If you have even the slightest doubt about your tires, replace them before you leave. Take time to pull lugs then re-torque to make sure it's an easy job if required on the road. At least pull the center caps of hubs to inspect and adjust bearing preload. I always carry spare bearings in addition to a complete hub assembled and ready to install.
A cordless grinder with a zip disk on it is handy if you need to remove a bearing race from a spindle roadside, and can be used to de-burr any damage.
I slide a 100 gallon transport tank/pump for fuel into bed, fuel stops become quick rest area pit stops with no hassle. Then top everything off when needed at truck stop.
Proper preparation and the trip is a breeze. Most likely your spare parts will only be used to rescue your buddies, as mine have done multiple times.

I have to second this - it has alerted me to hazards and speed traps on too many occasions to count.

Ryan

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Hmmm, that looks like maui

It's a "frog" on a beach. Close enough!

Join BOATUS and add the roadside assistance insurance (its like $15) to your membership. If you end up needing a tow it pays for itself 100x over. Don't ask me how I know

FWIW, I have AAA RV+ coverage. It covers ALL of my vehicles, including a trailer for roadside and towing.
If I break down towing, they send 2 trucks.

All great advice. But to much over thinking. It's good to be prepared that's obvious. But just get on 95 and point the truck south. Tons of hotels along the way

Make sure which I'm sure you already have, replace tires if needed, RRbrakes and system. AAA has cheap insurance for towing your trailer and it is not covered on basic plan. Good Luck!

Having made the NJ to Florida and reverse trips multiple times, I prefer 95 to 81. 81 does have less cities and local traffic but the mountains and winding through them make for a much more stressful trip. I prefer the straight flat run of 95.
This is just my opinion.